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International Journal of Zoology and Applied Biosciences Research Article
Formulation development and characterization of Azelnidipine loaded Nanosponges for enhance drug delivery
Shakeeb Akhtar Nehal Ahmad, Shahzad Ahmed Abdul Razzaque, Tarique A. Deshmukh, Hammad Mohammed Athar, Mohd Aatif Khan Rizwan Khan, Junaid Peer Md. Khatik
Year : 2026 | Volume: 11 | Issue: 4 | Pages: 1-6
Received on: 11/03/2026
Revised on: 19/03/2026
Accepted on: 04/05/2026
Published on: 01/07/2026
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Shakeeb Akhtar Nehal Ahmad, Shahzad Ahmed Abdul Razzaque, Tarique A. Deshmukh, Hammad Mohammed Athar, Mohd Aatif Khan Rizwan Khan, Junaid Peer Md. Khatik( 2026).
Formulation development and characterization of Azelnidipine loaded Nanosponges for enhance drug delivery
. International Journal of Zoology and Applied Biosciences, 11( 4), 1-6.
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Abstract
Nanosponges are microscopic sponges comparable in size to a virus (250 nm-1 ?m) that possess cavities capable of being filled with various hydrophobic and hydrophilic medications, effectively addressing challenges related to drug toxicity and poor absorption. Azelnidipine, a selective calcium channel blocker, effectively lowers blood pressure (BP) and heart rate (HR) in hypertensive patients. In the present study nanosponges of Azelnidipine were formulated and characterized for enhance drug delivery. Different batches with varying concentration of drug and excipient (A1, A2, A3, and A4) of Azelnidipine loaded nanosponges were prepared by emulsion solvent diffusion method. All the fabricated nanosponges of Azelnidipine combined with ethyl cellulose were characterized using FT-IR, DSC, XRD. As well as particle size determination, drug content and invitro release study. It was concluded that the prepared Nanosponges exhibited favourable drug content along with optimal drug release. Considering the biocompatibility of nanosponges, the development of Azelnidipine nanosponge formulations holds potential for the creation of various dosage forms and administration routes.
Keywords
Nanosponges, Azelnidipine, Enhance drug delivery, FT-IR, XRD.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
