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International Journal of Zoology and Applied Biosciences Research Article
Neuropharmacological evaluation of sedative hypnotic and anxiolytic effects of ethanolic leaf extract of Plumeria pudica in experimental mice
Bolisetty Padmavathi, Malle Srinivasa Akhil, Dasari Divya, Charitha Reddy Beeravalli and Rama Rao Nadendla
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 87-93
Received on: 29/05/2026
Revised on: 21/06/2026
Accepted on: 22/07/2026
Published on: 01/09/2026
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Bolisetty Padmavathi, Malle Srinivasa Akhil, Dasari Divya, Charitha Reddy Beeravalli and Rama Rao Nadendla( 2026).
Neuropharmacological evaluation of sedative hypnotic and anxiolytic effects of ethanolic leaf extract of Plumeria pudica in experimental mice
. International Journal of Zoology and Applied Biosciences, 11( 5), 87-93.
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Abstract
The present study evaluated the phytochemical constituents and sedative-hypnotic activity of the ethanolic leaf extract of Plumeria pudica Jacq. Preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, saponins, phenolic compounds, tannins, and glycosides. Acute oral toxicity was assessed according to OECD guideline 423 and experimental doses were selected accordingly. Sedative hypnotic activity was evaluated in Swiss albino mice using phenobarbitone- and thiopental-induced sleep models, while locomotor and anxiolytic activities were assessed using open field, elevated plus maze, and rota-rod tests. The extract produced a dose-dependent reduction in sleep onset latency and an increase in sleep duration, along with decreased locomotor activity and anxiolytic effects. The findings support the traditional use of Plumeria pudica in sleep-related disorders and indicate its potential as a natural sedative hypnotic agent.
Keywords
Plumeria pudica, Insomnia, Sedative-hypnotic activity, Phytochemical screening, Anxiolytic activity.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
