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International Journal of Zoology and Applied Biosciences Review Article
A review on in-vitro and in-vivo models of vitiligo
Jhansi lakshmi V, Priya Pati, Shaik Sumaiah Banu, Kolli Vaishnavi, Chochupatla V.N.V Sri Varsha, Sri Sai Vasanthi Sirki
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 124-128
Received on: 12/05/2026
Revised on: 26/06/2026
Accepted on: 26/07/2026
Published on: 01/09/2026
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Jhansi lakshmi V, Priya Pati, Shaik Sumaiah Banu, Kolli Vaishnavi, Chochupatla V.N.V Sri Varsha, Sri Sai Vasanthi Sirki( 2026).
A review on in-vitro and in-vivo models of vitiligo
. International Journal of Zoology and Applied Biosciences, 11( 5), 124-128.
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Abstract
Vitiligo is an acquired, progressive depigmentary disorder that is characterized by the loss of functional melanocytes resulting in clear skin depigmented lesions. The pathogenesis of vitiligo is multifactorial and complex: despite the development of clinical and molecular research, the occurrence of oxidative stress, autoimmune deficiency, genetic predisposition, and an intrinsic vulnerability of melanocytes remain unaddressed. Powerful experimental models are thus needed in mechanistic exploration and therapeutic development. The review is a critical expression of the models presently used in vitiligo studies both in vitro and in vivo. various invitro models that are discussed include cytokine treated melanocyte models, oxidative stress and ferroptosis, keratinocyte-melanocyte interactions, 3D skin equivalents, ipsc-derived melanocyte. in vivo models include various mice models such as C57BL/6 mouse model, Human skin xenocraft mice, smyth line chicken model, UV-induced vitiligo rat model.
Keywords
Vitiligo, Depigmentation, In vitro models, In vivo models, Melanocyte.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
