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International Journal of Zoology and Applied Biosciences Research Article
Controlled release microspheres of eplerenone: formulation and characterization
Rajkiran Kolakota, Gembali Manoj kumar, S. Likitha, Hanumanthu Likhitha
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 64-67
Received on: 27/05/2026
Revised on: 17/06/2026
Accepted on: 22/07/2026
Published on: 01/09/2026
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Rajkiran Kolakota, Gembali Manoj kumar, S. Likitha, Hanumanthu Likhitha( 2026).
Controlled release microspheres of eplerenone: formulation and characterization
. International Journal of Zoology and Applied Biosciences, 11( 5), 64-67.
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Abstract
Eplerenone is a mineralocorticoid receptor antagonist indicated in hypertension and heart failure. Frequent dosing due to its short half-life may lead to poor patient compliance and fluctuating plasma levels. This study aimed to formulate and evaluate sustained release microspheres of Eplerenone using different polymers to achieve controlled drug release for enhanced therapeutic efficacy. Microspheres were prepared by the solvent evaporation/ionic gelation technique using natural (sodium alginate) and synthetic polymers (ethyl cellulose and Eudragit RS100). The formulations were characterized for particle size, surface morphology, encapsulation efficiency, drug content, in vitro drug release, and release kinetics. Compatibility between drug and polymers was assessed by FTIR spectroscopy. Microspheres exhibited mean particle sizes ranging from 50 to 150 µm. Encapsulation efficiencies ranged from 68.5% to 91.2%, with optimized formulation (E6) showing 91.2%. FTIR analysis confirmed drug-excipient compatibility. In vitro release studies demonstrated sustained drug release up to 12-16 hours. Kinetic data fitted best with the Higuchi model, indicating diffusion-controlled release. Sustained release microspheres of Eplerenone were successfully developed, showing good morphology, drug-loading efficiency, and sustained release profiles, indicating potential for reduced dosing frequency and improved patient adherence.
Keywords
Eplerenone, Microspheres, Sustained release, Sodium alginate, Ethyl cellulose, Polymer encapsulation.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
