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International Journal of Zoology and Applied Biosciences Research Article
Development of hybrid polymeric microspheres for sustained delivery of atorvastatin
Rajkiran Kolakota, Gembali Manoj kumar, P.Anu, Gedela jayalaxmi
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 60-63
Received on: 22/05/2026
Revised on: 12/06/2026
Accepted on: 19/07/2026
Published on: 01/08/2026
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Rajkiran Kolakota, Gembali Manoj kumar, P.Anu, Gedela jayalaxmi( 2026).
Development of hybrid polymeric microspheres for sustained delivery of atorvastatin
. International Journal of Zoology and Applied Biosciences, 11( 5), 60-63.
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Abstract
Atorvastatin, a widely used HMG-CoA reductase inhibitor, requires long-term administration for effective management of hyperlipidemia. Conventional dosage forms may cause significant plasma level fluctuations and reduced patient compliance. The present investigation aimed to develop and evaluate sustained release microspheres of Atorvastatin using various natural and synthetic polymers to achieve controlled drug release and improved therapeutic outcomes. Microspheres were prepared by solvent evaporation technique using polymers such as sodium alginate (natural), Sod.CMC and Chitosan (synthetic), and combinations thereof. Formulations were evaluated for particle size, morphology, encapsulation efficiency, drug content, in vitro drug release, and release kinetics. Fourier Transform Infrared (FTIR) spectroscopy was used for compatibility studies. Microspheres exhibited mean particle sizes between 60-180 µm and encapsulation efficiencies ranging from 65.2% to 93.5%. The optimized batch (A6) containing sodium alginate:Chitosan (100:200) showed the highest encapsulation efficiency and sustained drug release of about 92.8% over 12 h. FTIR analysis confirmed absence of significant drug-excipient interaction. Drug release followed Higuchi kinetics, indicating diffusion-controlled release. Sustained release Atorvastatin microspheres were successfully developed. The optimized formulation demonstrated satisfactory encapsulation, desirable release characteristics, and potential for enhanced patient compliance through controlled release behavior.
Keywords
Atorvastatin, Microspheres, Sustained release, Sodium alginate, Chitosan, Encapsulation efficiency.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
