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International Journal of Zoology and Applied Biosciences Research Article
Formulation and evaluation of transferosomal mupirocin gel for enhanced skin permeation
Sonali Devne, Jyoti Jawale, Ankita Shinde, Rutuja Kendre, Vedika Patil, Neelam Bhagdewani, Smita Waghmare, Pramod Ingale
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 246-253
Received on: 08/06/2026
Revised on: 19/07/2026
Accepted on: 20/08/2026
Published on: 30/09/2026
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Sonali Devne, Jyoti Jawale, Ankita Shinde, Rutuja Kendre, Vedika Patil, Neelam Bhagdewani, Smita Waghmare, Pramod Ingale( 2026).
Formulation and evaluation of transferosomal mupirocin gel for enhanced skin permeation
. International Journal of Zoology and Applied Biosciences, 11( 5), 246-253.
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Abstract
Skin infections are among the most frequent bacterial infections and often require effective topical antibiotic therapy. Mupirocin is a widely used topical antibiotic, but conventional formulations may show limited skin penetration, short residence time and the need for frequent application, which can reduce therapeutic performance and patient compliance. This article aimed to formulate a Mupirocin loaded transferosomes using the ethanol injection method and added into a Carbopol based gel to improve topical delivery and antibacterial efficacy. The prepared transferosomal system was evaluated for particle size, polydispersity index, zeta potential, pH, drug content, spreadability, in vitro drug release, ex vivo permeation and antimicrobial activity. The optimized formulation showed nanosized vesicles, acceptable physicochemical properties, good stability and improved drug permeation compared with conventional gel. In vitro and ex vivo studies indicated sustained release and enhanced skin transport, while antimicrobial testing confirmed better antibacterial performance. The study concluded that the Mupirocin-loaded transferosomal gel is a promising topical drug delivery system for the effective treatment of bacterial skin infections due to its improved penetration, sustained release, and enhanced antibacterial efficacy.
Keywords
Franz diffusion cells, Sustained Release, Polydispersity Index, Dialysis Membrane.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
