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International Journal of Zoology and Applied Biosciences Research Article
Green synthesis and characterization of Breynia retusa mediated silver nanoparticles and their in vitro antiurolithiatic activity against struvite crystals
Mullai Nila K, Priya G and Chanthuru A
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 265-273
Received on: 08/06/2026
Revised on: 23/07/2026
Accepted on: 17/08/2026
Published on: 30/09/2026
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Mullai Nila K, Priya G and Chanthuru A( 2026).
Green synthesis and characterization of Breynia retusa mediated silver nanoparticles and their in vitro antiurolithiatic activity against struvite crystals
. International Journal of Zoology and Applied Biosciences, 11( 5), 265-273.
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Abstract
Urolithiasis remains a significant clinical challenge, necessitating eco-friendly therapeutic approaches. This study investigates the green synthesis of silver nanoparticles (AgNPs) using ethanolic stem extract of Breynia retusa and evaluates their antiurolithiatic potential. Phytochemical screening revealed abundant bioactive compounds, with tannin (0.128 mg/g) and phenol (0.02 mg/g) as dominant constituents. AgNPs were synthesized via reduction of AgNO?, confirmed by a surface plasmon resonance peak at 467 nm. Characterization using FTIR, XRD, SEM, and EDX indicated crystalline, spherical nanoparticles with sizes ranging from 72-90 nm and silver content of 64.81%. In vitro struvite crystal growth inhibition was assessed using a gel diffusion method. The highest inhibition (89.8%) was observed at 5% AgNP concentration, significantly reducing crystal mass from 2.46 g (control) to 0.25 g. These findings demonstrate that B. retusa-mediated AgNPs exhibit potent antiurolithiatic activity and offer a promising, sustainable alternative for kidney stone management.
Keywords
Urolithiasis, Breynia retusa, FTIR, XRD, SEM, EDX.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
