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International Journal of Zoology and Applied Biosciences Research Article
Neuroprotective role of umbelliferone in the Drosophila model of rotenone-induced parkinson’s disease
R. Ranjani, P. Subasri, A. Justin Thenmozhi, T. Manivasagam
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 20-31
Received on: 27/05/2026
Revised on: 19/06/2026
Accepted on: 25/07/2026
Published on: 01/09/2026
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R. Ranjani, P. Subasri, A. Justin Thenmozhi, T. Manivasagam( 2026).
Neuroprotective role of umbelliferone in the Drosophila model of rotenone-induced parkinson’s disease
. International Journal of Zoology and Applied Biosciences, 11( 5), 20-31.
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Abstract
Umbelliferone (UMB) is a coumarin derivative present ubiquitously in plants and demonstrated to have neuroprotective effects in rodent models of focal cerebral ischemia-reperfusion, MPTP-induced PD, sporadic AD and chronic unpredictable mild stress-induced depression. However, the neuroprotective role of UMB against an experimental model of PD has not yet been investigated. The aim of the present study is to examine the protective effect of UMB against rotenone-induced reduction in lifespan, cognitive impairment and oxidative stress in Drosophila melanogaster. Flies were divided into control, rotenone-treated, rotenone + UMB (25, 50 and 100µM) and UMB alone-treated. The duration of lifespan, cognitive (thermotaxis, smell and taste chemotaxis and phototaxis) and behaviour studies (open-field test and negative geotaxis) and biochemical (ROS, TBARS, SOD, catalase and GSH) assays were performed. UMB co-exposure attenuated the rotenone-induced reduction in lifespan, locomotion and cognitive impairment and oxidative stress in flies through its potent antioxidant properties. Our results indicated the protective role of UMB against rotenone-mediated neurotoxicity in flies could be partially due to its potent antioxidant function. Moreover, further in vivo and in vitro studies are needed to understand the precise neuroprotective mechanisms.
Keywords
Drosophila melanogaster, Rotenone, UMB, Oxidants, Antioxidants, Behaviour.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
