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International Journal of Zoology and Applied Biosciences Research Article
Smart pharmacosomes: Stimuli-responsive platforms for precision drug targeting
P.N.Mallikarjun, Endra Yerni kumari, Mulakapalli Sharmila, Janarajupalli Rajesh, Dadala Neha Pravallika, Kintahada Divya Madhuri
Year : 2026 | Volume: 11 | Issue: 5 | Pages: 100-105
Received on: 27/05/2026
Revised on: 20/06/2026
Accepted on: 22/07/2026
Published on: 01/09/2026
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P.N.Mallikarjun, Endra Yerni kumari, Mulakapalli Sharmila, Janarajupalli Rajesh, Dadala Neha Pravallika, Kintahada Divya Madhuri( 2026).
Smart pharmacosomes: Stimuli-responsive platforms for precision drug targeting
. International Journal of Zoology and Applied Biosciences, 11( 5), 100-105.
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Abstract
A sophisticated type of lipid-based drug delivery systems called stimuli-responsive pharmacosomes is intended to provide site-specific and regulated medication release. The active pharmaceutical ingredient is covalently bonded to phospholipids to generate self-assembling nanostructures with improved stability, solubility, and bioavailability, which are known as pharmacosomes. On-demand and targeted medication release at sick locations is made possible by the integration of stimuli-responsive mechanisms, which include external triggers like magnetic fields, light, ultrasound, and electric fields, as well as interior triggers like pH, redox potential, enzymes, and temperature. This review thoroughly examines the structural traits, materials, characterization methods, preparation processes, and therapeutic uses of stimuli-responsive pharmacosomes. Their function in the treatment of cancer, inflammatory conditions, neurological diseases, infectious diseases, and the transport of phytoconstituents is given particular attention. Additionally addressed are recent developments, legal issues, and prospects for the future, such as personalized treatment and smart systems enabled by nanotechnology. All things considered, stimuli-responsive pharmacosomes present a viable way to increase therapeutic effectiveness while lowering systemic toxicity.
Keywords
Pharmacosomes, Lipid-drug conjugates, Site-specific drug release, Smart nanocarriers, pH.
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© The Author(s) 2026. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
