Archives
International Journal of Zoology and Applied Biosciences Review Article
Comparative Genomics: A modern-day approach for understanding the blue print of life
Gayatri Bhatt, Sushil Bhattarai, Priyanka Negi, Vaibhavi Thapa, Swastika Nandy and Saranya Joshi
Year : 2025 | Volume: 10 | Issue: 1 | Pages: 15-28
Received on: 21/01/2025
Revised on: 26/01/2025
Accepted on: 30/11/-0001
Published on: 26/01/2025
-
Gayatri Bhatt, Sushil Bhattarai, Priyanka Negi, Vaibhavi Thapa, Swastika Nandy and Saranya Joshi( 2025). Comparative Genomics: A modern-day approach for understanding the blue print of life. International Journal of Zoology and Applied Biosciences, 10( 1), 15-28.
-
click to view the cite format
Abstract
Comparative genomics is an inevitable tool for carrying out studies related to evolutionary history of an organism. It unveils the scientific language of nature residing inside the genome of each organism by creating baseline data which is helpful in exploration of studies related to proteomics and drug discovery. The present study elaborates the various aspects associated with comparative genomics by detailing the useful tools available online for this approach. The study also describes a detailed methodology of comparative genomics involving the comparison of genome structure, coding regions and non-coding regions. It also encompasses the technical challenge involved in the approach which is the alignment of the whole genome of organisms. Recommendation has been made for development of tools required for robust comparison of non-coding regions for the identification of regulatory elements involved in controlling the gene expression of the organism which may help in providing significant leads for identification of genes associated with diseases and ailments.Keywords
Comparative Genomics, Whole Genome Alignment, Phylogenetic studies, coding
