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International Journal of Zoology and Applied Biosciences Research Article
Evaluating the functional outcomes of platelet rich plasma in knee osteoarthritis treatment
S. Kusuma Kumari, G. Naga Surekha, V. Thriveni, M. Hemalatha, K. Hima Bindu, B. V Ramana and K. Chandrasekhar
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 81-87
Received on: 22/01/2026
Revised on: 18/02/2026
Accepted on: 29/03/2026
Published on: 01/05/2026
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S. Kusuma Kumari, G. Naga Surekha, V. Thriveni, M. Hemalatha, K. Hima Bindu, B. V Ramana and K. Chandrasekhar( 2026).
Evaluating the functional outcomes of platelet rich plasma in knee osteoarthritis treatment
. International Journal of Zoology and Applied Biosciences, 11( 3), 81-87.
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Abstract
Knee osteoarthritis (OA) is a chronic, progressive degenerative joint disease that leads to pain, stiffness, and loss of mobility. Platelet-Rich-Plasma (PRP) therapy has recently gained prominence as a biological treatment modality due to its ability to promote cartilage healing, reduce inflammation, and improve joint function. This study aimed to evaluate the functional outcomes of intra-articular PRP therapy in patients with knee OA by analysing improvements in pain, stiffness, and physical function. The study also investigated potential predictors of therapeutic response based on demographic and clinical characteristics. A prospective observational study was conducted over six months in the Department of Orthopedics at Government General Hospital. Sixty patients with clinically and radiographically confirmed knee OA (predominantly Kellgren–Lawrence Grade 2) were enrolled. Data collected included age, sex, occupation, comorbidities, disease duration, and radiographic severity. All participants received intra-articular PRP injections, and their functional status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index and the Visual Analog Scale (VAS) at baseline and six weeks post-treatment. The mean age of participants was 52.5?±?8.98 years, and 61.7% were female. Comorbid conditions were present in 45% of patients, with hypertension being the most common (21.7%), followed by Asthma were present with 11.7% of patients followed by Pancreatitis were present with 6.7%, followed by Pneumonia were present with 5%. Baseline WOMAC scores significantly improved from 53.2?±?9.5 to 40.7?±?9.1 (p?<?0.001) after six weeks. Pain scores reduced from 13.8?±?3.4 to 9.2?±?2.9, stiffness scores from 4.6?±?1.5 to 3.1?±?1.2, and physical function scores from 35.1?±?7.2 to 28.2?±?6.9 (all p?<?0.001). VAS scores also demonstrated significant improvement, shifting from moderate to mild pain in most patients. PRP therapy significantly improved clinical outcomes in patients with early to moderate knee OA. It offers a safe, effective, and minimally invasive alternative for functional improvement and symptomatic relief.
Keywords
Platelet-Rich Plasma, Knee Osteoarthritis, Intra-articular Injection, Pain Management, Regeneration.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
