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International Journal of Zoology and Applied Biosciences Research Article
Formulation and evaluation of floating tablets of repaglinide using hydrophilic polymers
G. Madhu Sudhan, D. Reshma Banu, C. S. Parameswari, B. V. Ramana
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 133-138
Received on: 12/02/2026
Revised on: 06/03/2026
Accepted on: 16/04/2026
Published on: 01/05/2026
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G. Madhu Sudhan, D. Reshma Banu, C. S. Parameswari, B. V. Ramana( 2026).
Formulation and evaluation of floating tablets of repaglinide using hydrophilic polymers
. International Journal of Zoology and Applied Biosciences, 11( 3), 133-138.
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Abstract
Repaglinide is an oral hypoglycemic agent used in the treatment of type II diabetes mellitus. In the present study, repaglinide was formulated into floating tablets by direct compression method. Tablets were prepared using different grades of hydroxypropyl methylcellulose (HPMC K4M, K15M and K100M), sodium alginate and Carbopol 934P either alone or in combination as release retardants, while sodium bicarbonate was used as a gas-generating agent. Preformulation studies including solubility, melting point and micromeritic evaluation were carried out. The prepared tablets were evaluated for physicochemical properties such as hardness, thickness, friability, weight variation, drug content and swelling behavior. The tablets showed acceptable properties with thickness ranging from 4.60–4.68 mm and hardness between 6.3–7.1 kg/cm². Sodium bicarbonate (14%) produced buoyancy lag time of less than one minute and total floating time of 26–34 hours. The optimized formulations showed sustained drug release up to 24 hours indicating that repaglinide floating tablets may serve as an effective gastroretentive drug delivery system.
Keywords
Repaglinide, Floating tablets, Gastroretentive drug delivery system, HPMC, Sodium alginate.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
