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International Journal of Zoology and Applied Biosciences Research Article
Uncharted genetic risks in idiopathic deep vein thrombosis: F2, proc, F9 variants and accessible precision pathways
Dayala Ravi kiran and D. Jothieswari
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 206-214
Received on: 22/02/2026
Revised on: 17/03/2026
Accepted on: 19/04/2026
Published on: 01/05/2026
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Dayala Ravi kiran and D. Jothieswari ( 2026).
Uncharted genetic risks in idiopathic deep vein thrombosis: F2, proc, F9 variants and accessible precision pathways
. International Journal of Zoology and Applied Biosciences, 11( 3), 206-214.
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Abstract
Idiopathic deep vein thrombosis (DVT) remains difficult to manage, as recurrence risk is high even after appropriate anticoagulation. Current risk assessment models depend mostly on clinical factors and oversimplify hereditary thrombophilia, grouping it as one category. Recent studies show that rare and population-specific genetic variants, particularly in F2, PROC, and F9, play a significant role in hypercoagulability among patients classified as having unprovoked DVT. Notably, rare PROC variants are increasingly recognized as major risk factors, with strong evidence from sequencing studies and functional analyses. In contrast, while F9 gain-of-function variants are biologically plausible contributors, direct epidemiologic evidence for their link to idiopathic DVT is still weak. Standard diagnostic algorithms estimate event probability but overlook genetic complexity, especially in underrepresented Asian and resource-limited populations. A stepwise approach that combines clinical triage, structured diagnostics, and targeted gene sequencing could improve risk assessment and be feasible for tertiary hospitals with limited resources. Key future steps include broadening genetic research to diverse populations and developing scalable precision care models for thrombosis prevention and management.
Keywords
Protein C, Factor, Prothrombin, Thrombophilia, Genetic Sequencing.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
