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International Journal of Zoology and Applied Biosciences Research Article
Bioprospecting mangrove-derived marine fungi for antifungal and anticancer secondary metabolites targeting Candida spp. and triple-negative breast cancer
S. Priya Grace, P. Nirmala and S. Sakthimeena
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 234-239
Received on: 05/03/2026
Revised on: 17/03/2026
Accepted on: 20/04/2026
Published on: 01/05/2026
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S. Priya Grace, P. Nirmala and S. Sakthimeena ( 2026).
Bioprospecting mangrove-derived marine fungi for antifungal and anticancer secondary metabolites targeting Candida spp. and triple-negative breast cancer
. International Journal of Zoology and Applied Biosciences, 11( 3), 234-239.
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Abstract
Mangrove ecosystems harbor diverse and largely unexplored marine fungi capable of producing unique bioactive compounds with significant therapeutic potential. This study aimed to isolate and evaluate marine fungi from mangrove sediments for antifungal activity against Candida species and anticancer efficacy against triple-negative breast cancer (TNBC) cell lines. Fungal isolates were obtained using standard microbiological methods, and secondary metabolites were extracted using organic solvents. Antifungal activity was assessed by agar well diffusion, revealing a maximum inhibition zone of 22 ± 1.3 mm against Candida albicans. Cytotoxic potential was evaluated using in vitro assays, with the most active extract showing 78.6 ± 2.1% cell inhibition at 100 µg/mL and an IC?? value of 42.5 µg/mL against TNBC cells. These findings demonstrate that mangrove-derived marine fungi possess potent bioactive properties, highlighting their potential as promising sources for the development of novel antifungal and anticancer therapeutics.
Keywords
Marine fungal metabolites, Antifungal activity, Candida albicans, Anticancer activity, Triple-negative breast cancer.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
