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International Journal of Zoology and Applied Biosciences Research Article
Design and development of herbal formulations for the treatment of topical skin disorders
K. Sunil Kumar, Sk. Aabid, Sk. Sameer, S. Pavan Kumar, V. Aswani
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 88-94
Received on: 24/01/2026
Revised on: 19/02/2026
Accepted on: 01/04/2026
Published on: 01/05/2026
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K. Sunil Kumar, Sk. Aabid, Sk. Sameer, S. Pavan Kumar, V. Aswani( 2026).
Design and development of herbal formulations for the treatment of topical skin disorders
. International Journal of Zoology and Applied Biosciences, 11( 3), 88-94.
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Abstract
The present study aimed to design, develop, and evaluate a polyherbal topical formulation for the treatment of skin infections and related dermatological disorders. Selected medicinal plants including Ocimum sanctum, Rubia cordifolia, Glycyrrhiza glabra, Pterocarpus marsupium, Nerium oleander, and Punica granatum were collected, authenticated, and extracted using Soxhlet extraction with suitable solvents. The developed formulations were evaluated for physicochemical properties such as pH, viscosity, spreadability, and extrudability. In-vitro drug diffusion studies were conducted using a Franz diffusion cell, while stability studies were carried out under ICH guidelines. The optimized polyherbal formulation exhibited acceptable physicochemical properties, good spreadability, and skin-compatible pH. FTIR analysis confirmed compatibility between extracts and excipients. The formulation demonstrated satisfactory drug diffusion and remained stable under accelerated stability conditions. The developed polyherbal topical formulation showed promising physicochemical characteristics, stability, and broad-spectrum antimicrobial activity. These findings suggest that the formulation may serve as a safe and effective alternative for the management of skin infections. Further in vivo and clinical investigations are required to confirm its therapeutic potential.
Keywords
Polyherbal formulation, Topical ointment, Medicinal plants, Antimicrobial activity, Herbal drug.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
