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International Journal of Zoology and Applied Biosciences Research Article
Evaluation of antiulcer and hepatoprotective activity of Aloe vera and Turmeric oral suspension in Wistar rats
S. Ashok Krishnan, Md. Sheenamini, Sk. Kamar Jaha, Repalle Jaya Chandra, Neelamsetti Bala Shankar, Dasari Chandrika Satya Mangadevi, K. Daniel Raju
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 299-307
Received on: 20/03/2026
Revised on: 24/04/2026
Accepted on: 01/05/2026
Published on: 31/05/2026
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S. Ashok Krishnan, Md. Sheenamini, Sk. Kamar Jaha, Repalle Jaya Chandra, Neelamsetti Bala Shankar, Dasari Chandrika Satya Mangadevi, K. Daniel Raju( 2026).
Evaluation of antiulcer and hepatoprotective activity of Aloe vera and Turmeric oral suspension in Wistar rats
. International Journal of Zoology and Applied Biosciences, 11( 3), 299-307.
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Abstract
Peptic ulcer disease (PUD) and drug-induced hepatotoxicity are significant global health problems associated with oxidative stress, inflammation, and cellular injury. PUD develops due to disruption of the gastrointestinal mucosal barrier, leading to ulceration mainly in the stomach and duodenum. Major causative factors include Helicobacter pylori infection, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol intake, and stress. The disease results from an imbalance between aggressive factors such as gastric acid, pepsin, and reactive oxygen species and protective factors including mucus secretion, bicarbonate, and mucosal blood flow. NSAIDs, particularly indomethacin, inhibit prostaglandin synthesis through COX-1 blockade, causing mucosal damage and ulcer formation. In experimental studies, indomethacin at 20 mg/kg reliably induces gastric ulcers in animal models. NSAIDs are also implicated in hepatic injury through the formation of reactive metabolites that induce oxidative stress and mitochondrial dysfunction. Drug-induced hepatotoxicity contributes significantly to acute liver failure and is characterized by elevated liver enzymes (AST, ALT, ALP, GGTP), increased bilirubin levels, and reduced protein and albumin concentrations. Histopathological changes include centrilobular necrosis, inflammatory infiltration, and hepatocellular degeneration. Natural products such as Aloe vera and Turmeric possess antioxidant and anti-inflammatory properties that may protect against gastric and hepatic damage. Bioactive compounds including acemannan, curcumin, and flavonoids exhibit cytoprotective and hepatoprotective effects by scavenging free radicals and stabilizing cellular membranes. This study aims to evaluate the antiulcer and hepatoprotective potential of an Aloe vera–Turmeric oral suspension in indomethacin-induced Wistar rat models using biochemical and histopathological parameters to determine its therapeutic efficacy.
Keywords
Antiulcer, Hepatoprotective, Aloe vera, Turmeric, Indomethacin, NSAIDs, Oral Suspension.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
