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International Journal of Zoology and Applied Biosciences Research Article
Evaluation of the effect of selected plant extract for neurodegenerative activity in mice model
Varpa Indra Choudhary, V. Umarani, D. Swathi and K. Shravan Kumar
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 67-73
Received on: 22/01/2026
Revised on: 19/02/2026
Accepted on: 17/03/2026
Published on: 01/05/2026
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Varpa Indra Choudhary, V. Umarani, D. Swathi and K. Shravan Kumar( 2026).
Evaluation of the effect of selected plant extract for neurodegenerative activity in mice model
. International Journal of Zoology and Applied Biosciences, 11( 3), 67-73.
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Abstract
This study evaluated the neuroprotective potential of Centella asiatica extract in a scopolamine-induced cognitive impairment model in mice. Behavioral assessments (Y-maze, Novel Object Recognition, Morris Water Maze) demonstrated significant improvements in working, recognition, and spatial memory, particularly at higher doses (400 mg/kg), with efficacy comparable to donepezil. Biochemical analyses revealed reduced acetylcholinesterase activity, attenuation of lipid peroxidation and nitrosative stress, restoration of antioxidant enzymes (SOD, CAT, GSH), and suppression of pro-inflammatory cytokines (TNF-?, IL-1?). Histopathological examination confirmed preservation of neuronal density and morphology in hippocampal CA1 and CA3 regions. Mechanistically, the extract exerted multimodal actions including cholinergic modulation, antioxidant defense, anti-inflammatory activity, and structural neuroprotection. These findings validate the traditional use of C. asiatica as a “brain tonic” and highlight its potential as a phytopharmaceutical candidate for managing cognitive decline and neurodegenerative disorders such as Alzheimer’s disease. While promising, further studies addressing bioavailability, chronic disease models, and clinical trials are necessary to establish translational applicability.
Keywords
Centella asiatica, Scopolamine, Cognitive impairment, Acetylcholinesterase inhibition, Antioxidant.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
