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International Journal of Zoology and Applied Biosciences Research Article
Formulation and optimization of sustained release tablets of linagliptin using hydrophilic polymers
S. Shashindar, P. Laxmi, K. Nagasree and K. Shravan Kumar
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 74-80
Received on: 24/01/2026
Revised on: 17/02/2026
Accepted on: 19/03/2026
Published on: 01/05/2026
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S. Shashindar, P. Laxmi, K. Nagasree and K. Shravan Kumar( 2026).
Formulation and optimization of sustained release tablets of linagliptin using hydrophilic polymers
. International Journal of Zoology and Applied Biosciences, 11( 3), 74-80.
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Abstract
The sustained release tablets containing Linagliptin (SR) were successfully formulated using the direct compression method. Evaluation of the powdered blends across all trials revealed compliance with official standards for flow properties, including angle of repose and compressibility index. The tablets exhibited consistent physiochemical characteristics such as thickness, hardness, weight variation, and friability. The optimized formulation L8 demonstrated a sustained drug release profile, releasing 8.7% of Linagliptin in the first hour, with sustained release continuing up to 24 hours. Stability studies over three months confirmed no significant changes in the physical and chemical properties of formulation L8, remaining within acceptable limits. Drug release kinetic analysis indicated adherence to zero order kinetics (R^2=0.966), highlighting controlled and consistent drug release. These results suggest that formulation L8, prepared by direct compression, is a promising and effective sustained release tablet for the treatment of HIV infection.
Keywords
Linagliptin, Sustained release tablets, Direct compression, Formulation L8, Zero-order kinetics.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
