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International Journal of Zoology and Applied Biosciences Research Article
Role of propranolol in decompensated liver disease: clinical profile safety and efficacy
M. Sri Ramachandra, S. Irshad Nufshrun, G. Kavya Reddy, D. Gammana Sree, G. Sucharitha
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 187-193
Received on: 19/02/2026
Revised on: 04/03/2026
Accepted on: 15/04/2026
Published on: 01/05/2026
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M. Sri Ramachandra, S. Irshad Nufshrun, G. Kavya Reddy, D. Gammana Sree, G. Sucharitha( 2026).
Role of propranolol in decompensated liver disease: clinical profile safety and efficacy
. International Journal of Zoology and Applied Biosciences, 11( 3), 187-193.
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Abstract
Decompensated Chronic Liver Disease (DCLD) is a life-threatening condition characterized by complications like ascites, variceal bleeding, and hepatic encephalopathy. This study aimed to assess demographics, clinical complications, and propranolol therapy outcomes in DCLD patients. This 6-month prospective observational study was conducted at Government General Hospital, Kurnool, involving 120 DCLD patients. Patient demographics, clinical complications, propranolol therapy, and liver disease severity were assessed using Child-Pugh and MELD scoring systems. Most patients were middle-aged males, presenting with ascites (common complication), esophageal varices, and hepatic encephalopathy. Propranolol was continued in 58.3% of patients. Treatment resulted in significant clinical improvements, notably in Child-Pugh scores. Adverse events led to discontinuation in some patients. The study highlights the substantial burden of DCLD in India and underscores the therapeutic utility of propranolol. Early detection and intervention, along with vigilant clinical monitoring and tailored management strategies, are crucial to reduce morbidity and mortality, particularly in alcohol-related liver disease.
Keywords
Acute Kidney Injury, Endoscopic Variceal Ligation, Hepatorenal Syndrome, MELD, DCLD.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
