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International Journal of Zoology and Applied Biosciences Research Article
Unveiling the anticancer potential of Andrographis paniculata and Ocimum sanctum: GC-MS, admet profiling and molecular docking
P. Vanmuhil, R. Karnan, M. Sakthivel, S. Thaila, M. Suganya, A.R. Balu, S. Ganesan
Year : 2026 | Volume: 11 | Issue: 4 | Pages: 239-248
Received on: 22/04/2026
Revised on: 14/05/2026
Accepted on: 22/06/2026
Published on: 31/07/2026
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P. Vanmuhil, R. Karnan, M. Sakthivel, S. Thaila, M. Suganya, A.R. Balu, S. Ganesan( 2026).
Unveiling the anticancer potential of Andrographis paniculata and Ocimum sanctum: GC-MS, admet profiling and molecular docking
. International Journal of Zoology and Applied Biosciences, 11( 4), 239-248.
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Abstract
Herbal-based treatment, the backbone of the Indian traditional medicine system since ancient times, is a response to the presence of phytochemicals. Globally, phytochemicals are recognized as remarkable and eco-friendly drugs, including for cancer treatment. The aim is to explore the anticancer bioactive phytochemicals from Andrographis paniculata and Ocimum sanctum leaves' ethanolic extract using GC-MS techniques, ADMET profiles, and molecular docking approach. Flavonoids, terpenoids, steroids, coumarins, tannins, saponins, and polyphenols are held by A. paniculata and O. sanctum. Additionally, GC-MS techniques revealed 15 phytochemicals in A. paniculata, while O. sanctum held 9 phytochemicals. The ADMET profile of Lipinski’s Rule was agreed on for suitability for the oral drug, and the molecular docking approach confirms the inhibition of cell proliferation and growth by 13-docosenamide (-5.00 Kcal/mol) and 9-octadecenamide (-4.90 Kcal/mol) on EGFR kinase (PDB: 3UG2). Overall, Andrographis paniculata leaves had rich phytochemical profiles compared to Ocimum sanctum leaves. Further present bioactive compounds need in vitro and in vivo studies for eco-friendly claims of cancer treatment and other pharmacological applications.
Keywords
Phytochemicals, Anticancer, Andrographis paniculata, Ocimum sanctum, In silico, ADMET.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
