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International Journal of Zoology and Applied Biosciences Research Article
Formulation and evaluation of domperidone microparticles using natural polymers by ionic gelation technique
G Meghana, D Reshma Banu, C.S.Parameswari, B.V.Ramana
Year : 2026 | Volume: 11 | Issue: 3 | Pages: 125-132
Received on: 12/02/2026
Revised on: 26/02/2026
Accepted on: 19/04/2026
Published on: 01/05/2026
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G Meghana, D Reshma Banu, C.S.Parameswari, B.V.Ramana( 2026).
Formulation and evaluation of domperidone microparticles using natural polymers by ionic gelation technique
. International Journal of Zoology and Applied Biosciences, 11( 3), 125-132.
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Abstract
The present study aimed to formulate and evaluate domperidone microparticles using natural polymers through an ionic gelation technique to achieve controlled drug release. Domperidone is an anti-dopaminergic drug widely used as a prokinetic and antiemetic agent. However, its short biological half-life necessitates frequent dosing, which may reduce patient compliance. In this work, microparticles were prepared using natural polymers such as pectin, guar gum, and xanthan gum with calcium chloride as a cross-linking agent. Preformulation studies including identification, solubility analysis, melting point determination, and compatibility studies were performed. The microparticles were evaluated for morphology, percentage yield, entrapment efficiency, particle size, and in-vitro drug release. The prepared microparticles were spherical and smooth in morphology. Entrapment efficiency ranged from 23.1% to 80.24%. Among the prepared formulations, F5 exhibited the highest entrapment efficiency while F7 showed prolonged drug release behavior. In-vitro dissolution studies indicated sustained drug release for up to 24 hours. The results demonstrate that domperidone microparticles prepared using natural polymers through ionic gelation can serve as an effective controlled drug delivery system.
Keywords
Domperidone, Microparticles, Ionic gelation, Natural polymers, Controlled release.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
